Resources

Explore additional resources of interest.
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Expert perspectives videos

Hear from the experts as they discuss the Ang–Tie pathway and its importance in retinal diseases.

VEGF inhibition and beyond: Building on existing foundations

Patricio G. Schlottmann, MD
Charles Wykoff, MD, PhD
Anat Loewenstein, MD

Introduction to angiopoietins

Pipsa Saharinen, PhD
University of Helsinki
Helsinki, Finland

Vascular stability: What is it really?

Patricio G. Schlottmann, MD
Organizacion Medica de Investigacion
Buenos Aires, Argentina

It’s all in the balance: Ang-1 vs Ang-2

Anat Loewenstein, MD
Tel Aviv Medical Center
Tel Aviv, Israel

Ang-2 and vascular instability: Explore the evidence

Charles Wykoff, MD, PhD
Retina Consultants of Houston
Houston, Texas, United States

Ang-2 promotes endothelial permeability

Pipsa Saharinen, PhD
University of Helsinki
Helsinki, Finland

Downloadable resources

Learn more about the role of angiopoietins in vascular stability and retinal disease.

Angiopoietins: Key regulators of vascular stability

Download a detailed illustration showing how Ang-1 and Ang-2 promote vascular stability or instability.

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FAQs

Find answers to common questions related to angiopoietins and retinal diseases.

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AMD, age-related macular degeneration; Ang, angiopoietin; CNV, choroidal neovascularisation; DR, diabetic retinopathy; DME, diabetic macular edema; RPE, retinal pigment epithelium; RVO, retinal vein occlusion; Tie, tyrosine kinase with immunoglobulin-like domains; VEGF, vascular endothelial growth factor.

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References

  1. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/retinal-diseases/symptoms-causes/syc-20355825 [last accessed August 2020]
  2. Gene. https://www.gene.com/patients/disease-education/age-related-macular-degeneration [last accessed August 2020]
  3. NEI. Facts about diabetic eye disease. https://nei.nih.gov/health/diabetic/retinopathy [last accessed August 2020]
  4. ASRS. https://www.asrs.org/patients/retinal-diseases/24/branch-retinal-vein-occlusion [last accessed August 2020]
  5. American Academy of Ophthalmology. Central retinal vein occlusion. https://www.aao.org/eye-health/diseases/what-is-central-retinal-vein-occlusion [last accessed August 2020]
  6. Thomas M, et al. Angiogenesis. 2009;12:125–37
  7. Saharinen P, et al. Nat Rev Drug Discov. 2017;16:635–61
  8. American Academy of Ophthalmology. https://eyewiki.org/Choroidal_Neovascularization%3A_OCT_Angiography_Findings [last accessed September 2020]
  9. University of Michigan Kellogg Eye Institute. http://kellogg.umich.edu/theeyeshaveit/opticfundus/retinal_neovascularization.html [last accessed September 2020]
  10. Scheppke L, et al. J Clin Invest. 2008;118(6):2237–46