Resources

Explore additional resources of interest.
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Expert perspectives videos

Hear from the experts as they discuss the Ang–Tie pathway and its importance in retinal diseases.
VEGF inhibition and beyond:
Building on existing foundations

Patricio G. Schlottmann, MD
Charles Wykoff, MD, PhD
Anat Loewenstein, MD

Introduction to angiopoietins

Pipsa Saharinen, PhD
University of Helsinki
Helsinki, Finland

Vascular stability: What is it
really?

Patricio G. Schlottmann, MD
Organizacion Medica de Investigacion
Buenos Aires, Argentina

It’s all in the balance: Ang-1 vs
Ang-2

Anat Loewenstein, MD
Tel Aviv Medical Center
Tel Aviv, Israel

Ang-2 and vascular instability: Explore the evidence

Charles Wykoff, MD, PhD
Retina Consultants of Houston
Houston, Texas, United States

Pathways mediating nAMD,
DME and DR

Stephan Michels, MD
Augenklinik Zürich West and University of Zürich
Zürich, Switzerland

Animated videos

Embark on an animated journey to discover the role of angiopoietins and vascular instability in DME and nAMD.

Ang–Tie signalling: An animated journey
Ang–Tie signalling: An animated journey – Pathologic conditions
Role of Ang-2 and VEGF in DME
Role of Ang-2 and VEGF in nAMD

Downloadable resources

Learn more about the role of angiopoietins in vascular stability and retinal disease.

Angiopoietins: Key regulators of vascular stability

Download a detailed illustration showing how Ang-1 and Ang-2 promote vascular stability or instability.

A closer look at vascular stability

Download a visual summary of how Ang-1 and Ang-2 regulate vascular stability.

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FAQs

Find answers to common questions related to angiopoietins and retinal diseases.

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AMD, age-related macular degeneration; Ang, angiopoietin; CNV, choroidal neovascularisation; DME, diabetic macular edema; DR, diabetic retinopathy; nAMD, neovascular age-related macular degeneration; RPE, retinal pigment epithelium; RVO, retinal vein occlusion; Tie, tyrosine kinase with immunoglobulin-like domains; VEGF, vascular endothelial growth factor.

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References

  1. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/retinal-diseases/symptoms-causes/syc-20355825 [last accessed November 2021]
  2. Genentech. https://www.gene.com/patients/disease-education/age-related-macular-degeneration [last accessed November 2021]
  3. NEI. Diabetic Retinopathy. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy [last accessed November 2021]
  4. ASRS. https://www.asrs.org/patients/retinal-diseases/24/branch-retinal-vein-occlusion [last accessed November 2021]
  5. American Academy of Ophthalmology. https://www.aao.org/eye-health/diseases/what-is-central-retinal-veinocclusion [last accessed November 2021]
  6. Thomas M, et al. Angiogenesis. 2009;12:125–37
  7. Saharinen P, et al. Nat Rev Drug Discov. 2017;16:635–61
  8. American Academy of Ophthalmology. https://eyewiki.org/Choroidal_Neovascularization%3A_OCT_Angiography_Findings [last accessed November 2021]
  9. University of Michigan Kellogg Eye Institute. http://kellogg.umich.edu/theeyeshaveit/opticfundus/retinal_neovascularization.html [last accessed November 2021]
  10. Scheppke L, et al. J Clin Invest. 2008;118(6):2237–46